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In further or alternative embodiments, the terminal groups of the poly(DL-lactide-co-glycolide) are either hydroxyl, carboxyl, or ester depending upon the method of polymerization

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Antioxidant enzymes such as catalase, glutathione peroxidase, and MnSOD remain vital to cellular defense, and FOXO4-DRI has been considered a tool to examine senescence while maintaining these protective systems

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