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Author Contributions Jos Luis Grriz provided expert clinical opinion and critical revision of the manuscript for important intellectual content and has helped establish the structure and contents of the manuscript

Phase 2 dose escalation protocol The Phase 2 trial evaluated multiple dose levels ranging from 0.5mg to 12mg administered once weekly via subcutaneous injection

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Further work is needed to investigate whether it is estradiol that mediates these sex differences in GLP-1 activity

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