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Roell, W

This has been put down to the initial slow-down of your gastric system when you're first using semaglutide

doi: 10.1016/j.ecoenv.2021.112947 150 YuanATStillmanMJ

Zepbound (tirzepatide) is a dual GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1) receptor agonist

At normal body temperature, the half-life of the enzyme is shorter than normal, leading to a decrease in fatty acid beta-oxidation and ATP generation

There is no definitively established causal relationship , but UK and European regulatory bodies have noted pancreatitis as a potential adverse effect in the Summaries of Product Characteristics (SmPCs) for GLP-1 receptor agonists