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Metabolic and amino acid alterations of the tumor microenvironment

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To offer a semi-quantitative yet predictive understanding of the mechanism, we formulate a kinetic model for the G protein signaling and desensitization by considering essential biochemical steps from ligand binding to receptor internalization

Moreover, malate metabolism by this enzyme plays a key role in interconversion of carbon residues in contributing biosynthetic pools of metabolites [71]

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