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Blocking FOXO4, which inhibits the activation of P53, causes senescent cells to undergo apoptosis by P53 activation, without affecting healthy cells around them, and has anti-aging effects which may have potential applications in the treatment of numerous age-related diseases, as well as an adjunct to treatment for certain forms of cancer

To this end, we first abrogated phosphate conjugation by mutating the serine residue at the 114 position to an alanine (S114A) within the ectopically expressed NHR-49::YFP transgene

validation, R.S