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PPAR deacetylation confers the antiatherogenic effect and improves endothelial function in diabetes treatment

10.1016/S1474-4422(15)70016-5 126 HerholzK.SalmonE.PeraniD.BaronJ

142 Hence, mTORC1-specific inhibitors or intermittent treatments that avoid disrupting mTORC2 or only reduce rather than eliminate mTORC1 pathway activity may constitute safer strategies for treating age-related diseases

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However, in mice that received peripheral administration of a high dose of fluorescein-ghrelin, the fluorescein signal was observed not only in the ARC and ME but also in the AP and paraventricular nucleus (PVN), suggesting that circulating ghrelin can traverse fenestrated capillaries and reach certain CVOs (55)

10.1021/tx500019u Chem