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Restoring DLX-mediated GABAergic neuron differentiation or enhancing GABA signaling (e.g., via GABAA receptor agonists) could potentially rescue circuit imbalances in DLX-related ASD subtypes

While delayed gastric emptying increases satiety and reduces caloric intake, excessive delay can result in gastric content retention, leading to upper abdominal discomfort

Randomized trial of fenretinide to prevent second breast malignancy in women with early breast cancer

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Thus, by silencing CDO1, NRF2-addicted cancer cells maintain a large intracellular pool of cysteine for the glutathione synthesis, resulting from the increased cysteine uptake by xCT and decreased cysteine decomposition