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The different expression levels observed in APP/PS1 animals, especially for the m- Gpx4 isoform, suggest a genotype-related transcriptional regulation, which fits well with the increased levels of hippocampal oxidative stress demonstrated in transgenic animals (Aso et al., Table 1 Oligonucleotides used as primers for quantification of different Gpx4 mRNA isoforms and for mapping 5 end of I - Gpx4 mRNA in HT22 cells and mouse hippocampus

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Impact of Toxins on P450 Enzymes and Methylation Exposure to toxins, drugs, and alcohol can impair the activity of P450 enzymes, leading to a decrease in SAMe production and impaired methylation

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