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[19] NAD + concentrations are highest in the mitochondria, constituting 40% to 70% of the total cellular NAD +

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Maddalena, G, Pellatt, AJ, Eluri, M, Parseghian, C, Aziz, KE, Alfaro, KD, Kell, R, Bent, AH, Huey, RW, Uppal, A, Konishi, T, Overman, MJ, Morelli, MP, Willis, JA, Shen, JY, Raghav, KS, Newhook, TE, Morris, VK, Dasari, NV, Kopetz, S

Apart from differential compartmentation, one possibility is that this array of enzymes guarantees robust redox homeostasis, even at the expense of redundancy, consistent with loss-of-function studies for APX and PRX isoforms in the chloroplast (Awad et al