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It enhances glucose-dependent insulin secretion, reduces plasma glucagon levels, delays gastric emptying, and modulates the hypothalamic hunger centers, leading to appetite suppression [62]

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Hydration status significantly affects periorbital appearance with dehydration exaggerating dark circles through increased blood viscosity pooling more visibly, skin dullness from reduced cellular hydration making circles more prominent, and impaired lymphatic function allowing fluid retention despite overall dehydration

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Slower digestion can make meals feel more satisfying for more of the day, helping reduce snacking or grazing. Cravings Decrease Semaglutide also affects reward pathways linked to cravings