Lilly describes it as an investigational triple hormone receptor agonist being studied for obesity and related conditions
As noted above, methanol is toxic and can cause dermatitis and transdermal absorption with systemic toxicity when absorbed by the skin and can be more injurious if consumed orally
A separate study published in August 2025 found patients prescribed semaglutide or tirzepatide for Type 2 diabetes had an increased risk of NAION and other optic nerve disorders, but the overall risk was very low
Major insurers like UnitedHealthcare, Cigna, Blue Cross Blue Shield, Aetna, Medicare Part D, and Medicaid often cover these medications when treating obesity or qualifying weight-related conditions
(2020) and Koushesh Saba and Watkins (2020) detected an increase in POX activity in apples suffering from CI
GLP-1 receptor agonists: Similar to tirzepatide, these injectable weight loss drugs called GLP-1 inhibitors have been found to be highly effective in lowering blood sugar levels by increasing insulin production and decreasing glucagon release from the pancreas