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Furthermore, the deletion of Bmal1 in the brain induced apoE expression (inhibiting, e.g., astrocytic clearance of A [73]), potentially elucidating how circadian disruption may increase A burden in the brain

Data availability The data presented in this study are available on request from corresponding author

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Nat Protoc (2006) 1(5):23159

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Specifically, 132 trials (50.3%) enrolled fewer than 50 participants, and 56 trials (21.3%) had sample sizes between 50 and 100 (Supplementary Fig