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The Journals of Gerontology: Series A, 2019

However, research evidence does not support this concern at typical research doses: Multiple long-term animal studies (extending to 2+ years) have not demonstrated increased cancer incidence Research on IGF-1 signalling in cancer cells shows context-dependent effects (some cancer cells proliferate in response, while others actually undergo differentiation or apoptosis) The IGF-1 receptor is found on essentially every cell type, yet selective activation does not consistently promote malignancy That said, individuals with personal or family history of certain cancers (particularly hormone-sensitive cancers like prostate or breast cancer) should approach IGF-1 LR3 with appropriate caution and medical consultation if applicable

Biol Trace Elem Res 2024, 10.1007/s12011-024-04302-5, doi:10.1007/s12011-024-04302-5

The most common adverse effects in the tesofensine group were dry mouth, nausea, constipation, hard stools, diarrhea, and insomnia

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Expression analyses For developmental conditions, expression data from Gene Expression Map of Arabidopsis Development (Schmid et al., 2005) were retrieved using the eFP browser (Winter et al., 2007)