Another second-line pharmacologic option is prucalopride, a 5-HT4 serotoninergic agonist, with an established dose applied orally every 24 hours.94,97 Prucalopride is a good option in patients that experience adverse effects related to GLP-1 agonists because it increases gastric emptying, augmenting rectal sensitivity and intestinal transit
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Dosing is titrated gradually over weeks to minimize side effects like nausea, and the pace of titration matters significantly for both tolerability and results
Gasbjerg LS, Helsted MM, Hartmann B, Sparre-Ulrich AH, Veedfald S, Stensen S, et al
Skeletal Effects of Growth Hormone and Insulin-like Growth Factor-I Therapy
Real-Time PCR The specificity of the PCR amplification with each primer pair was electrophoretically confirmed with a 4% NuSieve 3:1 agarose gel (Cambrex Corporation, USA)
