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To interpret the data above, it's important to understand the experimental conditions from the key study cited [1]

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(Menopause definitely counts as a time of stress!) Epidemiological studies have shown higher vitamin C plasma concentrations in women, suggesting that women may need more of it than men , and low concentrations in both sexes have been associated with symptoms of aging, including cognitive decline

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Further studies and additional models are needed to clarify whether this reflects increased toxicity or immune activation

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