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If someone wants rapid, large weight loss, prescription injectable medicines like semaglutide (injectable) or tirzepatide (injectable) produce much larger average reductions in controlled trials, though they are a different category of therapy and come with their own tradeoffs
Watch for possible symptoms, such as a lump or swelling in the neck, hoarseness, trouble swallowing, or shortness of breath
There are trials that are not well conducted and are very, very biased, she said
This method is considered appropriate if the relative treatment effect can be assumed to be the same across the two trial populations, which was deemed to hold in the populations of SUSTAIN 7 and AWARD-11 (both conducted in people with type 2 diabetes with inadequate glycaemic control on metformin)
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