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A tour de force in enzymology converts a bacterial dehalogenase into a self-labeling enzyme, including extensive semi-rational optimization and demonstration of the power of the covalent labeling across a range of methods

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In addition, using organs-on-chips to co-culture pancreatic endothelial cells, immune cells, and islets would highlight the mechanisms of human immune cell infiltration and validate the observations made in animal models

A study in mice has demonstrated that this peptide has antimicrobial effects