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Statistical analysis The characteristics of the study population were summarized using descriptive statistics

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Lipid peroxidation assay and enzyme-linked immunosorbent assay (ELISA) analysis Tissue lipid peroxidation markers, including malondialdehyde (MDA), glutathione (GSH), glutathione peroxidase (GSH-Px), and Fe 2+ contents, were detected following the respective manufacturers protocols

Meanwhile, SAM maintains the activated conformation, which is essential to enzyme functio