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Similarly, those dealing with hyperpigmentation or melasma may notice a more even skin tone and reduced dark spots

Cells were mixed with 50 L of Matrigel in a centrifuge tube to achieve a concentration of 1 10 6 cells

Importantly, THC shows an excellent safety profile: acute toxicity studies revealed no adverse effects at doses up to 10,000 mg/kg [13], while sub-chronic administration (400 mg/kg) caused no significant toxicological findings [18]

Elevated ROS reinforce TGF-/Smad signaling, driving hepatic stellate cell transdifferentiation into myofibroblasts and fibrogenesis [414]

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