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Cette enzyme permet de rduire le disulfure de glutathion en glutathion l'aide de NADPH provenant notamment de la voie des pentoses-phosphates chez les bactries, les plantes et les animaux afin de rgnrer le glutathion, molcule essentielle la rsistance contre le stress oxydant et la prservation du pH intracellulaire [3] , [4] , [5]