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Gastrointestinal adverse events, predominantly mild-to-moderate in severity, were more frequently reported with semaglutide compared to placebo (82.2% versus 53.9%)

Slide from FLOW session, 61st European Renal Association Congress Sample Size and Analytic Plan This trial was event-driven, with a minimum of 854 primary outcome events (including 515 kidney events) which would provide 90% power to detect a 20% risk reduction

The Retatrutide participants lost around 24.2% over 48 weeks at the highest dose

It promotes angiogenesis, upregulates growth factor receptors, and interacts with the FAK-paxillin pathway involved in cell migration and wound healing