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Reports on safety concerns included observational data suggesting that GLP-1 RAs, especially the more potent agents are not associated with significantly increased risks for pancreatitis or medullary thyroid carcinoma

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This gap reflects a combination of limited clinician familiarity with prescribing guidelines, concerns about medication safety, and barriers to insurance coverage

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However, preclinical studies demonstrate therapeutic effects with once-daily or even less frequent administration, suggesting tissue distribution, receptor binding, or cellular signaling effects extend beyond plasma clearance