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Guan R, Yang Q, Yang X, Du W, Li X, Ma G (2022) Efficacy and safety of tirzepatide in patients with type 2 diabetes mellitus: a Bayesian network meta-analysis

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Semaglutide GLP-1 also slows down how quickly your stomach empties, allowing you to feel fuller for longer and thus diminishing your overall caloric intake

In comparison, the STEP-1 trial reported that 2.4mg/weekly semaglutide led to side effects in 89.7% of the subjects, with the most common complaints being [17]: Nausea (44.2% of subjects) Diarrhea (31.5%) Vomiting (24.8%) Constipation (23.4%) Dyspepsia (10.3%) Abdominal pain (10% Gallbladder-related events (2.6%) The majority of gastrointestinal reactions were of mild to moderate intensity, temporary, and resolved without needing a permanent halt in treatment