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Together, this combination helps your body lose and manage weight

Many people taking GLP-1s find that they eat smaller meals and eat and drink less overall, which can at times lower energy availability for exercise and contribute to dehydration

Studies show that the higher maintenance dose in Wegovy produces meaningfully greater weight loss

Common symptoms include: Dry mouth or extreme thirst

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Dec 18, 2025, 08:00 ET CagriSema 2.4 mg/2.4 mg is an investigational fixed-dose injectable medicine that combines the novel amylin analogue, cagrilintide, with semaglutide to target complementary obesity-related pathways 1,2 In the REDEFINE 1 phase 3 trial, adults with obesity, or overweight with at least one obesity-related complication, taking CagriSema lost an average of 23% body weight when evaluating the treatment effect if all patients stayed on treatment *2 Novo Nordisk continues to build on its 100-year-plus legacy of science and innovation, with potential new treatments in obesity PLAINSBORO, N.J