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Journal of Drugs in Dermatology : JDD,10(9)

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These follow-on patents, also known as secondary patents, mainly consist of formulations, combinations with other drugs, methods of treating different indications that were alreadydisclosed in the main compound patents, and drug delivery devices

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This intracellular conversion has been confirmed pharmacokinetically: in a peer-reviewed human bioavailability crossover trial, SAG was undetectable in plasma following oral administration because rapid deacetylation occurs before or immediately upon systemic entry meaning the entire SAG load is converted to GSH before reaching blood circulation

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