Even those who eventually tolerate high concentrations well typically experience problems when starting there
--- The Human Study: What They Did The study followed patients diagnosed with chronic knee pain including osteoarthritis, patellofemoral syndrome, and post-injury degenerative changes who had not achieved adequate relief from standard interventions including physical therapy, NSAIDs, and corticosteroid injections
without the need for IF, and that high doses (1000 g per day) of oral B12 can therefore be effective even in pernicious anaemia
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Simple Explanation of Half-Life Half-life refers to the amount of time it takes for half of a substance to leave the bloodstream or become metabolized by the body