doi:10.17245/jdapm.2022.22.2.97 Sikiric P, Seiwerth S, Rucman R, et al
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FIGURE 8 Atherosclerosis, a chronic inflammatory disease, may be an ideal environment for the high viral replication capabilities of SARS-CoV-2 in human cells, enhancing hyper-inflammation secondary to immune system dysregulation (Figure 9) that leads to adverse outcomes, as shown in patients with cardiovascular risk factors (258, 259)
However, the activation of STAT3 signaling stimulates a negative feedback response through the induction of SOCS factors which not only inhibit the activity of insulin/IGF-1 receptors but also that of many cytokine receptors
By conducting thorough genetic analyses, we can offer personalized risk assessments and genetic counseling to at-risk individuals, empowering them with knowledge about their genetic predisposition to Graves disease
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