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Early ME/CFS had prominent activation of pro-inflammatory cytokines such as TNF and IL-1, and anti-inflammatory cytokines such as IL-1, compared with controls

Obesity contributes to 30% to 53% of new Type 2 diabetes cases every year

This damage can disrupt the respiratory chain, impair ATP production, and cause a loss of the electrical potential difference across the inner mitochondrial membrane (), a hallmark of mitochondrial dysfunction

Plus, both exercise and GLP-1s can lower blood sugar

Because all the conditions really stem from a central problem, which is excess dysfunctional adiposity, or changes in fat tissue that can trigger insulin resistance, cardiovascular disease, sleep apnea, kidney disease and other complications