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Mechanistically, LRRFIP1 bound to the E2F transcription factor 6 (E2F6) promoter to suppress E2F6 transcription, thereby downregulating a key differentiation regulator, CCAAT enhancer binding protein alpha (C/EBP)

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It is advisable to avoid layering multiple copper-containing products within the same regimen, as cumulative exposure may elevate copper levels beyond what is considered safe for topical use