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J Proteomics 2012, 75, 3351-3364, doi:10.1016/j.jprot.2012.03.038

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Side Effects of Metformin as a Life-Extension Drug As a mild mitochondrial poison, metformin carries a variety of downsides

MC-1R is found in melanocytes in the skin and is primarily involved in the darkening of the skin, and helps the skin produce melanin

While they are increasingly popular for addressing various skin concerns, it's crucial to prioritize safety and consultation with a qualified dermatologist or skincare expert

People who take certain blood thinners, suffer from asthma, or have glaucoma should be aware of potential mild side effects