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doi: 10.1016/j.neuropharm.2014.10.007 73 Aviles-OlmosIDicksonJKefalopoulouZDjamshidianAEllPSoderlundTet al

These injections use hydroxocobalamin, and research indicates that oral supplementation can offer absorption comparable to injections in many situations

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But with a 2mg/mL concentration (5mL of water added), that same 4mg dose requires 2.0mL of liquid, which is an entire insulin syringe worth and creates a large, uncomfortable injection volume