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Previous studies using the liver cancer cell line HepG2 under normoxic or hypoxic conditions showed that melatonin reduces VEGF expression by disrupting physical interaction between phosphorylated STAT3, HIF-1, and transcriptional coactivator/p300/CBP on the VEGF promoter

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Disruptions in glucose homeostasis caused by p53 increase circulating glucose levels, which is a characteristic of type 2 diabetes (T2D)