In patients with herpesvirus CNS infections, bloodbrain barrier disruption can increase ACV concentrations, which may lead to acyclovir-induced neuropsychiatric symptoms (AINS) associated with high cerebrospinal fluid levels of the metabolite 9-carboxymethoxymethylguanine (CMMG) [57]
Costa and Labuc, 1994
For example, altered levels of short-chain ACs, including C2 and C3, have been observed in coronary artery disease and diabetes [6, 55]
Relevant markers include malondialdehyde (MDA), 8-isoprostane, reduced glutathione (GSH), and high-sensitivity CRP
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