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Direct head-to-head comparisons between metformin monotherapy and Rybelsus specifically for weight loss are limited, as both medications are primarily studied and prescribed for glycaemic control in diabetes
Donald Vollmer of Body Works in Franklin, TN a clinic that offers GLP-1 therapy, peptide therapy, and hormone optimization under one roof notes that patients who combine medication with structured diet and exercise consistently achieve better body composition outcomes than those who rely on medication alone
It also upregulates over 4,000 genes involved in tissue repair, angiogenesis, and antioxidant defense while downregulating pro-inflammatory and pro-fibrotic pathways
Esses VM, Herman CP
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