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Endogenous GLP-1 has a very short half-life (approximately 12 minutes) due to rapid degradation by the enzyme dipeptidyl peptidase-4 (DPP-4)

132,133,134 Canonical Wnt signalling acts indirectly on -catenin to enhance its stability, allowing it to translocate from the cell surface to the nucleus, thereby linking extracellular signalling to nuclear gene expression regulation through downstream transcriptional machinery (Fig

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