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In the U.S., its a leading cause of disability

Although low levels of reactive oxygen species (ROS) mediate critical physiological signaling pathways, accumulation of raised levels, if not cleared rapidly, can lead to major deleterious consequences affecting several organs, such as the heart, kidney, eye and brain, culminating in a variety of human disorders (Forman and Zhang 2021)

HSV-1 presents several advantages that position it as a leading candidate for oncolytic virotherapies

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