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By methylating and removing nicotinamide, NNMT effectively drains NAD+ precursor availability, leading to reduced intracellular NAD+ levels

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In the model proposed by Lee, homocysteine is shunted away from the methionine synthesis pathway and toward the GSH synthesis pathway, creating a relative deficiency of methyl donors in order to keep up with increased demand for the glutathione needed for POP conjugation ( Fig 3 )

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Destruction of the thyroid and ovaries may be caused by greater exposure to autoantibodies, and the consequence of both disorders may be insulin resistance, impaired glucose tolerance, weight gain, and infertility