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its one of a dozen-plus peer-reviewed randomized NMN and NR trials in humans that show this same pattern: What about IV or injectable NAD+

Wilmer MJ, Emma F, Levtchenko EN (2010) The pathogenesis of cystinosis: mechanisms beyond cystine accumulation

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Primary keratinocyte culture is limited by their variability in culture conditions, and their susceptibility to irritants varies with the number of passages