Research also suggests that certain peptides help extend the biological activity of GLP-1, essentially keeping it around longer
Important cautions include avoiding use in patients with severe gastroparesis or other severe gastrointestinal disease, monitoring for diabetic retinopathy complications (particularly in patients with pre-existing retinopathy), and avoiding use during pregnancy with a recommended washout period of at least 2 months before planned conception
Many patients with grade 1/2 toxicities are able to resume immunotherapy after treatment
59 Recently, the SURMOUNT-5 trial demonstrated that tirzepatide was superior to semaglutide in obese patients without diabetes with respect to reductions in body weight and waist circumference at week 72
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We speculate that in the presence of functional DNA repair mechanisms and physiological levels of FA, FA-caused DNA damage would be alleviated before it reaches the threshold required for triggering apoptosis