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Figure 3CF summarize the results for secondary outcomes

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19,20 The increase in mucus production, and the decrease in CFTR activity can precede COPD and persist once disease is established, 21 indicating that the presence of oxidant stress plays a role in the early onset of disease and is an attractive therapeutic target

Kooijman et al (1995) have studied the effects of IGF-2 on the development of T-cells in two transgenic mouse lines overexpressing the human IGF-2 gene under the control of the H2Kb promoter

How will my progress be monitored, and when should I report concerns