γ-glutamyl linkage glutathione Concise review: gamma-glutamyl transferase GLUTATHIONE SYNTHESIS - PMC

Lancet Oncol 18(7):863-873, 2017

In certain embodiments, any controlled release otic formulation or composition described herein increases the exposure of a therapeutic agent and increases the Area Under the Curve (AUC) in otic fluids (e.g., endolymph and/or perilymph) by about 30%, about 40%, about 50%, about 60%, about 70%, about 80%, or about 90% compared to a formulation or composition that is not a controlled release otic formulation or composition

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However, serum levels may be maintained at normal or borderline levels at the expense of tissue concentrations

C57BL/6J mice, common inbred strain of laboratory mouse

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