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Histidine, an essential amino acid, is metabolised to histamine and can affect the contractility of bronchial smooth muscle and cause airway oedema 50

Once liver damage has occurred, it cannot be reversed

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The pathogenesis involves a combination of cell-mediated and humoral immune responses, initiated in genetically predisposed individuals upon exposure to environmental triggers

In addition to the roles of the GH/IGF axis in pathological conditions of the muscular system, studies have reported an important role of the GH/IGF axis in physiological conditions of the tendon and skeletal muscle