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Strategies to Minimize Weight Regain After Semaglutide The most effective approach combines tapering (gradual dose reduction rather than abrupt cessation), lifestyle consolidation, and planned maintenance therapy

However, there is uncertainty about long-term benefit in terms of sustained weight loss and CV benefit, as well as the impact of potential tolerability concerns

Int J Mol Sci 21(10)

The clinical data is clear on that

Combined global sales of GLP-1 RAs exceeded tens of billions in 2025, fueling massive profitability for the developers

Talk with your health care team before stopping these types of weight-loss drugs