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Tesamorelin affects hepatic IGF-1 production and gluconeogenesis

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In line with UK SmPCs for approved GLP-1 receptor agonists, use is generally not recommended in individuals with a personal or family history of medullary thyroid carcinoma or MEN2, or in those with a history of pancreatitis

Retatrutide remains investigational

"When you think about normalizing obesity and the treatment of it, people are used to taking a pill for hypertension or for high cholesterol, so here's another way that it just normalizes it to take a pill for a condition that we know is a chronic disease," Narula said