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The primary and key secondary outcomes in included studies PIONEER 1 to 6, 8 and 9 were based on objective outcomes, such as A1C, body weight, and time to first occurrence of MACE, and therefore would be less impacted by potential bias introduced from the open-label study designs or inferred randomization

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Important Safety Considerations Before Starting This Combination Bupropion carries a black box warning for increased seizure risk and suicidal ideation, especially in patients under age 25