B12 shots are generally safe, and side effects are rare
Q: What makes B12 injections better than oral supplements
In addition to reducing or eliminating the symptoms of B12 deficiency, research suggests that B12 shots may: Reduce stress (7) Support central nervous system function, red blood cell formation, and DNA synthesis (2) Reduce the risk of vision loss from age-related macular degeneration (8) Lower homocysteine levels, which is associated with cardiovascular disease and stroke (9, 10)
Most patients are in and out within 510 minutes
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Additionally, the fed state typical of evening hours may reduce absorption efficiency compared to morning fasted dosing