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The overexpression of p53, SAT1, ALOX15 proteins, and iron accumulation may lead to ferroptosis in cells, and higher expression levels of p53, SAT1, and ALOX15 proteins could be associated with more severe muscle inflammatory lesions and increased muscle damage [229]

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However, these rates have increased compared to 2025, when 27% of MA-PD enrollees faced coinsurance for preferred brands and 56% faced coinsurance for non-preferred drugs

There is a need for new, safe, and effective therapeutics with extensive safety and efficacy data that can be developed for use in humans within the next few years

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