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In particular, we found reduced efficacy for sustained insulin secretion with lixisenatide using an in vitro beta cell system, as well as reduced anti-hyperglycaemic and anorectic effects in mice

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(1992) Stereospecific glutathione conjugation of (R)- and (S)-2- bromoisovalerylurea in freshly isolated rat kidney tubular cells Biochem

However, they are not approved medicines and are not subject to the same rigorous testing or regulation as prescription medications like GLP-1 injections