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The effects of PYC on stimulated macrophage cell cultures to mimic the immune response identified that the most active metabolite of PYC, M1 (-(3,4-dihydroxyphenyl)--valerolactone), mediated anti-inflammatory effects by impeding nitric oxide generation and inducible nitric oxide synthase (iNOS) upregulation production (Uhlenhut and Hgger, 2012)

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