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The Glucagon-like peptide-1 receptor agonist, exendin-4, ameliorated gastrointestinal dysfunction in the Wistar Kyoto rat model of Irritable Bowel Syndrome

In the 64-week OASIS 4 trial (307 adults), mean weight loss was 13.6% under the treatment-policy analysis and 16.6% among participants who stayed on treatment, versus about 2% on placebo

3D and Table 6, among females less than 40 years old, NSAID usage was associated with a greater reduction in HbA1C in response to GLP-1 M (0.82 1.72) than no NSAID usage (0.28 1.70, Bonferroni adjusted p = 8E-03)

The sample was 655 Ro patients, median age 45.8, 67.9% women, median BMI 32.3

GLP-1 receptor agonists reduce liver fat content and improve markers of liver inflammation

doi: 10.1172/jci.insight.164921